Itaconic acid is a platform chemical currently produced by Aspergillus terreus. Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades.
Itaconic acid. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors Jonathan M. Weiss, 1 Luke C. Davies, 2 Megan Karwan, 3 Lilia Ileva, 3 Michelle K. Ozaki, 4 Robert Y.S. Consequently, this review does not only address the historical and present development in IA research, but also emphasises the importance of small scale screening for new biorefinery processes. Itaconic acid is an organic acid that is … The itaconic acid biosynthesis pathway ... and even the design of new microbial production platforms.

(9) compared the regulation of itaconic acid production in A. terreus with that of citric acid production in A. niger. Therefore, we focus in this report on the recent advances with an emphasis on the biochemistry of the process and new genetic engineering targets.

It has a role as a fungal metabolite and a human metabolite.

Historically, itaconic acid was obtained by the distillation of citric acid, but currently it is produced by fermentation.The name itaconic acid was devised as an anagram of aconitic acid, another derivative of citric acid.

Control of cellular metabolism is critical for efficient cell function, although little is known about the interplay between cell subset–specific metabolites in situ, especially in the tumor setting. Other organisms, including Aspergillus niger and yeasts, have been engineered to produce itaconic acid. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate -aconitic acid. The fertilizer additive products Nutrisphere and Avail use a coating of maleic–itaconic acid copolymer and have been marketed worldwide. Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. These acids are used as building blocks for large numbers of compounds, such as resins, paints, plastics, and synthetic fibers (acrylic plastic, super absorbants, and antiscaling agents) [67].The CAC intermediate cis-aconitate is enzymatically processed by cis-aconitate dehycarboxylase (CadA) to produce itaconic acid [68].

In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate -aconitic acid. The fertilizer additive products Nutrisphere and Avail use a coating of maleic–itaconic acid copolymer and have been marketed worldwide. 1. • In combination with acrylamide to form (poly[acrylamide-co-(itaconicacid)]) to synthesize biodegradable superabsorbent polymers.
Itaconic Acid (IA) Latest Industry Research Report On global Itaconic Acid (IA) Market Research Report 2019 in-depth analysis of the market state and also the competitive landscape globally.. For readability purposes, only the pictograms, signal words and hazard statements referred to in more than 5% of the notifications under CLP are displayed. Description: Itaconic acid is a dicarboxylic acid that is methacrylic acidin which one of the methyl hydrogens is substituted by a carboxylic acid group. polymers Review Biomass-Derived Production of Itaconic Acid as a Building Block in Specialty Polymers Bernadette-Emoke˝ Teleky 1 and Dan Cristian Vodnar 2,* 1 Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăstur¸ 3-5, 400372 Cluj-Napoca, Romania; bernadette.teleky@usamvcluj.ro Their adsorption properties were evaluated in batch experiments for Cd(II) or Pb(II) uptake. Itaconic acid (IA) can be used: • As a comonomer in the polymerization of polyacrylonitrile (PAN) to promote the thermo-oxidative stabilization of polymer. To understand the regulation of itaconic acid production, Bonnarme et al. Owing to environmental reasons, there is a gradual demand for renewable resources in the chemical industry. Many fungi can synthesize itaconic acid; Aspergillus terreus and Ustilago maydis produce up to 85 and 53 g l−1, respectively.

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